Side effects of iodine-negative thyroid cancer targeted therapy
Solodyannikova O.I., Bankovska N.V., Danylenko V.V., Turitsyna V.L.
Summary. The aim of the work is to assess the effect on the effectiveness of treatment of iodine-negative metastases of differentiated thyroid cancer (DTC) with the help of tyrosine kinase inhibitors, side effects of targeted therapy. Research methods and equipment – scintigraphy of the whole body with 99mTc-MIBI; whole body scintigraphy with 99mTc-DMCA; positron emission tomography with 18F-FDG; methods of statistical processing of results; two-detector gamma camera of the company «Mediso» (Hungary), single-photon emission computed tomography (SPECT) «E. CAM 180». Results. 60 patients with DTC were treated with the targeted drug sorafenib, scintigraphy of whole body with 99mTc-MIBI was performed in order to evaluate the therapeutic effectiveness by scintigraphic imaging. A method of treatment with drugs, tyrosine kinase inhibitors, of iodine-negative metastases of DTC has been developed.A scintigraphic evaluation of the effectiveness of treatment using PET with 18F-FDG was carried out in 20 patients with DTC and iodine-negative metastases. In 8 patients, in whom bone damage was detected, treatment was carried out with the help of radionuclide and remote radiation therapy. Control of treatment effectiveness was carried out using scintigraphy of whole body with 99mTc-MDP. Conclusions. In this way, the revealed side effects of targeted therapy of iodine-negative metastases prove the need for regular monitoring with the help of radionuclide non-iodine imaging methods.
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