About the creation of the concept of lung cancer development
Bolhova L., Tuganova T., Alekseenko O.
Summary. The high incidence of lung cancer (LC) (2.1 million) and mortality from it (1.7 million) every year worldwide is a major problem in oncopulmonology. It is known that LC is diagnosed in 60–70% of patients in stage III–IV when it is no longer possible to conduct a course of special therapy. Such situation requires a comprehensive study of the problem of LC. Such a provision requires a comprehensive study of the problem of LC. One of the main issues is the study of histogenesis, which determines on the accuracy of morphological diagnosis, the nature of treatment and its effectiveness. Conducting scientific research on the morphological diagnosis of LC, we managed to find data from the literature that allowed us to clarify the intricacies of the structure of the lung, which is of direct importance before the development of pathological processes in the organ — this is the place of transition of the bronchial epithelium into the alveolar one. It has been proven that the place itself is the most vulnerable in the development of the pathological process. The established lung stem cell is an alveolar epithelium of the second type, from which any pathological process in the lung, including lung cancer originates. The results of our research have showed that the onset LC growth begins under the cylindrical epithelium. According to numerous histological preparations of squamous cell, glandular and small cell types of cancer, the growth of LC from the basal membrane of the alveolus to its center, where necrosis develops, is revealed as a well-known fact of the pathogenesis of epithelial tumors that occurs with a lack of blood supply. Thus, taking into account the data of fundamental publications involved in the problem of LC and the results of our research, we established that lung cancer begins its growth from the transition point of the basal epithelium of the bronchus and grows in the alveoli. The phenomenon we have established is a priority, not described in the literature and explains the asymptomatic onset of the development of LC and low survival rate.
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