Role of genetic polymorphism of glutathione-S-transferase in the prediction of chemotherapy complications

Summary. Most patients with malignant breast tumors require chemotherapy. Often, complications that developed as a result of chemotherapy, significantly impair the efficacy of treatment and reduce patients quality of life. Study of the gene polymorphism of glutathione-s-transferases in patients receiving chemotherapy is a promising molecular genetic diagnostic criterion for identifying the risk of complications, individual risk assessment and implementation of preventive measures to reduce the toxicity of chemotherapy.