INTERACTIONS BETWEEN LEUKEMIC CELLS AND MICROENVIRONMENT IN CHRONIC LYMPHOCYTIC LEUKEMIA: NEW ASPECTS OF PATHOGENESIS AND TARGET THERAPY

Summary. Modern data concerning mechanisms of interaction between leukemic cells and microenvironment in chronic lymphocytic leukemia (CLL) are presented. The main cellular signaling pathways and new approaches to therapy of CLL patients based on inhibition of kinase activity, tumor necrosis factor proteins (BAFF, APRIL), and modulation of immunogenity of leukemic cells are discussed.