MORPHOFUNCTIONAL TYPES OF NUCLEOLI IN DYSPLASIA OF COLUMNAR EPITHELIUM AND CERVICAL ADENOCARCINOMA

Summary. The study of nucleolar organizer regions of chromosomes (NORC) in the cells of dysplastically altered columnar epithelium and cervical adenocarcinoma (CAC) has revealed a gradual increase of quantitative content of the main morphofunctional types of nucleoli, including active compact and transient nucleolonemic-compact ones in parallel with an appearance of cytomorphological signs of atypia. The prevalence of the percent content of large argentophylic granules in nucleoli of nucleolonemic type in tumor cells compared to dysplastic ones, has been demonstrated. The obtained data reflect the character and degree of structural-functional changes of NORC, according to which an algorithm of differential cytological diagnostics of columnar epithelium dysplasia and CAC has been developed thus allowing more correct evaluation of pathological process.