Bisphosphonates and their role in treatment of bone system tumors (review)

Summary. The literature review to estimate the efficiency of bisphosphonates in complex treatment of primary bone malingnancies was performed. They demonstrated the pathogenetic mechanisms of therapeutic effect of bisphosphonates. Bisphosphonates cause antiresorptive effect on bones and also an antitumor effect. Bisphosphonates combined with chemotherapy improve the results of treatment of bone malignancies. Bisphosphonates may improve the stability of limb reconstruction following bone resection.