Increase capability of chemoradiotherapy efficacy of patients with advanced breast cancer by using radiomodificated agents

Summary. The article describes effective methods of chemoradiotherapy of patients with locally advanced forms of breast cancer using radiomodificated agents (tegafur and microelements’ complex) during the radiotherapy. 106 breast cancer patients have been conducted the chemoradiotherapy. At the first treatment stage all patients received four courses of polychemotheraphy on the modified scheme FAC. Patients of the first main group (34 patients) was conducted radiotherapy on the background of cytostatic agent ftorafur at radiomodifying doses 1200 mg daily per os. Patients of the second main group (36 patients) were put on the complex of microelements before an irradiation session, in the dose of 1 drop for 1 kg bodyweight three times a day per os (on the average 20 drops triple a day) at 8, 11 and 14 o’clock followed by radiotherapy from 15 till 19 o’clock. Patients of the control group (36 patients) received radiation therapy according to the standards of care. Obtained data indicate more efficacy of chemoradiotherapy of patients with locally advanced forms of breast cancer in the main groups, where radiotherapy was followed by using radiomodificated agents (tegafur and microelements’ complex).