Bcl-2 and p53 expression in neuroblastic tumors’ cells with different nucleic acids content

Summary. High frequency of bcl-2 and p53 expression in neuroblastoma (NB) compared with ganglioneuroblastoma (GNB) coincides with the total anaplasia grade in these tumors type. However, comparison of polyploid GNB and NB reveals considerable similarity of bcl-2 and p53 expression pattern among their cells. Accordingly, the difference between the GNB and NB caused by NB properties, which are defined as diploid. The lack of clear correlation between the DNA amount and bcl-2 or p53 expression among neuroblastic tumors cells gives reason to believe these signs as the mutually independent prognostic criteria, which are caused by different pathogenetic mechanisms of oncogenesis.