Prognostic value of high-grade prostatic intraepithelial neoplasia

Summary. Prostate cancer (PCa) is a major problem in health care around the world. The ability to accurately detect early forms of prostate cancer and associated pre-cancerous lesions is certainly desirable. Prostatic intraepithelial neoplasia (PIN) is a precursor lesion for PCa development and structurally characterized by benign glands and ducts, covered with atypical cells without anatomical distribution outside the capsule, what confirms the nature of the pre-cancerous lesions of the prostate. Most tumors are diagnosed in the first re-biopsy of the highest stage, the degree and volume, and these patients obviously benefit from the intervention versus conservative management. The present review analyzes recent data on the relationship between the high grade PIN and PCa. We established that patients with initial diagnosis of isolated high grade PIN re-biopsy should be considered mandatory. To solve the problem of optimal management of patients with localized forms of PCa and quality of life associated with surgery on prostate cancer, we need to analize large prospective study with a longer follow-up.