Effectiveness of support therapy algorithms based on chemotherapy toxicity prognostic factors in patients with breast cancer

Summary. Chemotherapy is a mandatory component of combined treatment of patients with locally advanced or metastatic breast cancer. Toxicity of chemotherapy should be considered with a view to the prevention and adequate treatment, as it: adversely affect the quality of life of patients both during treatment and at follow-up, makes it necessary to reduce the dose of cytotoxic drugs, increase the intervals between cycles and stop cancer treatment, can be life-threatening, significantly increases the cost of treatment. Application of the algorithm of support therapy in standard chemotherapy regimens in patients with malignant breast tumors with a high risk of chemotherapy-related complications allowed to perform chemotherapy without delay and dose reduction, and decrease the incidence of gastrointestinal toxicity in the form of emetic syndrome by 30.0%, early hepatotoxicity — by 8.2% and early cardiovascular toxicity — by 25.1%, as a result has been improved outcomes and quality of life of patients.