Colorectal cancer: pathogenetic descriptiveness histological studies (review)
Antonyuk S.A.1, Vorobey E.A. 2, Savchyn T.M.
Summary. Histological study, including histo- and immunohistochemistry, provides a huge amount of data about the state of colorectal cancer (CRC). They display as histological type and level, where differentiation of the tumor, and its main malignant properties — unlimited growth and invasion/metastasis, can determine pathogenic pathways of its development, already considered as prognostic factors. However, today, the widespread use of biomarkers, except related to targeted therapy, has not found a meaningful clinical application. This is not a lack sign of relevance or renewal methods, and due to some organizational problems, in our opinion in the first place, with the lack of simple methods adapted evaluation of certain features in a heterogeneous cell system, which is the CRC. Determination by multivariate analysis of highly informative prognosis criteria, the definition of the typical phenotypic tumors profiles will provide an effective tool for improving the efficiency of the colorectal cancer treatment. Given that the multifactorial tumors assessment is very laborious, a prerequisite for its widespread introduction into routine clinical practice is the development of algorithms and methods for its implementation, including automated.
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