Problems with mobilization of peripheral blood stem cell in children with solid tumors

Summary. Only adequate number of peripheral blood stem cells ensures the implementation of high-dose chemotherapy safety. Which is why, mobilization and collection is an extremely important element of high-dose chemotherapy. According to many studies, the probability of inefficient collection of hematopoietic stem cells is 14–40%. Purpose is to examine effectiveness of peripheral blood stem cell mobilization in children with malignant solid tumors. We analyzed the mobilization procedure in 133 children with malignant solid tumors who were treated in the department of pediatric oncology in the period from 2008 to 2013. The first mobilization procedure was effective in 71 (53.4%) patients. In 24 (18.0%) children was unable to obtain the necessary amount peripheral blood stem cell.