Breast cancer prognostic factors. Current state of the problem

Summary. Analysis of breast cancer prognostic is a key moment for understanding the disease natural history, assessment of individual prognosis and response for treatment. At present, the most significant prognostic factors are: stage of the disease, tumor size, resection margins status and tumor cells in lymphatic and blood vessels, regional lymph node involvement, histological type and grade, receptor status (expression of estrogen and progesterone receptors, HER2/new). Very useful information may present the studies, aimed to the comparison of the prognostic value of the data, obtained with genetic studies and widely affordable immunohistochemisrty.