Impact of modulators of arginine and polyamines level on the metabolic activity of macrophages, the cytolytic activity of splenocytes and their electrokinetic properties in mice with L1210 leukemia

Summary. It has been shown that inhibitors of polyamines level significantly increase the metabolic activity of macrophages and simultaneously reduces the cytolytic activity of splenocytes from animals with experimental leukemia. Arginase inhibits the metabolic activity of the cells of leukemia L1210 in vitro. Between the ζ-potential and metabolic activity of leukemia cells and macrophages of tumor-bearing there is an inverse correlation.