Modern possibilities of differential cytological diagnostics of proliferating mesothelium, mesothelioma and cancer metastases (literature review and results of own research)

Summary. The review presents an analysis of national and foreign literature on differential cytological diagnostics of proliferating mesothelium, mesothelioma and cancer metastases during microscopic examination of effusion fluids with the use of modern methods. Cytomorphological features are presented at descriptive level providing for the development of their objectification for improvement of the diagnostics. In many cases cancer cells from serous fluids loss immunocytochemistry profile or carry the distorted expression of markers, therefore special monoclonal antibodies for refinement of differential diagnostics are required. Modern approaches for identification of mesothelial cells and metastatic tumors are analyzed, and also there are assigned the tasks which should be worked out for improvement of their cytological diagnostics.