Urodynamic study in patients with invasive cervical cancer

Summary. In oncogynecology, the use of radical interventions in patients with invasive cervical cancer (CC) leads to a number of complications in urinary and reproductive systems, such as dysfunction of urinary bladder, genitourinary fistula, chronic renal insufficiency, sexual disorders, decreased quality of life. For evaluation of disorders of urinary bladder and urethra it is necessary to carry out an objective analysis of the function of lower urinary tract that could be performed via a complex urodynamic study. It is reasonable to perform a complex urodynamic study in CC patients because it allows to reproduce patient’s symptoms, objectively explain a mechanism underlying these disorders, and reveal the most significant defect in the case of combined character of dysfunction of lower urinary tract. Pathogenesis of urinary system dysfunction is complex and poorly understood yet. It is supposed that the main cause of the development of such disorders is a trauma of pelvic autonomic plexuses in CC patients during radical intervention. Urination disorders result from a trauma of sensitive and motor neurons of detrusor during nerve-sparing operations in CC patients. Therefore, for evaluation of urinary and reproductive system functions, cystometry as a component of a complex urodynamic study has been discussed.