Рaget’s disease of the nipple: review of the literature and retrospective evaluation of own data

Summary. Paget’s disease of the nipple composes 1–4.3% of all breast tumors. Due to the fact that this pathology is uncommon in the population, today there are no recommendations based on large randomized studies that would regulate the optimal treatment strategy. A retrospective research about the features of diagnostics and treatment of Paget’s disease of the nipple was made. It included 17 patients with Paget’s disease of the nipple (age from 34 to 87) that had been treated during the 2001–2013 in Bogomolets National Medical University Oncology Clinic based on the surgical department of Municipal Clinical Cancer Center. 24 patients (control group) were diagnosed of I–II stage breast cancer of other histological structure. The study revealed that Paget’s disease of the nipple often occurs with invasive component (82%) and exp­ressing HER2/new. The 3-year overall survival of patients with Paget’s I–II stage cancer is not different from the one of other breast cancer histological types.