Central nervous system involvement prophylaxis in patients with diffuse large B-cell lymphoma

Summary. Modern treatment of patients with diffuse large ­B-cell lymphoma allows to achieve quite high survival rates. However, there are some unsolved problems, including secondary central nervous system (CNS) involvement. Prophylaxis and treatment of this rare and fatal complication are among the most difficult tasks in oncohematology. The article is dedicated to the literature review in prognosis and prophylaxis of secondary CNS involvement. The own data in the frequency of CNS involvement in patients who either underwent or not CNS prophylaxis are given as well.