Endocrine resistance as a problem in the treatment of breast cancer

Summary. Breast cancer — is the most frequent pathology among females with oncological diseases. Endocrine therapy is widely used metod of breast cancer treatment. Anti-estrogen agents, aromatase inhibitors are very often used in the treatment regimens of hormone-dependent breast tumors. It should be noted that today is increased the number of endocrine resistant tumors. It directly affects the severity of disease and survival of patients. The basic mechanisms of the different phenotypes of endocrine resistance are reviewed in the article. The attention is focused on the molecular and pharmacokinetic mechanisms of endocrine resistance development in patients with breast cancer.