PET-CT impact for early detection of ovarian cancer recurrence

Summary. The aim of the study to evaluate the sensitivity, specificity and accuracy of positron emission tomography and computed tomography (PET-CT) for detecting recurrent ovarian cancer (OC). The retrospective study was performed. There were analyzed the data of OC patients whom PET-CT was performed in the Kyiv City Clinical Oncology Center between 2011 and 2015. All patients received initial combined therapy. The overall sensitivity of PET-CT was 93%, specificity — 100%, the false negative and false positive rates — 4 and 0%, respectively, accuracy — 96%, positive and negative predictive value – 93 and 100%, respectively. PET-CT allows to detect OC recurrence with high sensitivity and specificity. The method should be used to monitor patients if there is a high risk of disease recurrence, doubtful results of other imaging techniques (ultrasound sonography, computed tomography, magnetic resonance imaging) and elevated serum CA-125 levels.