Influence of clinical factors of unfavorable prognosis on the results of treatment of children with malignant solid neoplasms of high-risk groups (department’s experience)
Summary. The most difficult problem in pediatric oncology treatment is prognostically unfavorable forms of solid malignancies at high risk. Achieving the best results of treatment of patients associated with the transition to a more intensive chemotherapy regimens, the use of high-dose chemotherapy with autologous peripheral blood stem cell transplantation, which allows to realize the phenomenon of «dose — effect» and thus improve results treating this group of patients and achieve 45–50% survival rate. In the research department of pediatric oncology at National Cancer Institute from 2004 to 2015 received high-dose chemotherapy with autologous peripheral blood stem cell transplantation 144 pediatric patients with unfavorable prognostic solid malignant tumors. The total three-year survival rate for children with Ewing’s sarcoma in a high risk group of carrying high-dose chemotherapy with autologous peripheral blood stem cell transplantation was 58%, and in the treatment of children with neuroblastoma of high-risk group — nearly 50%.
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