Antitumor and immunomodulating effect of dendritic cells loaded with magnetic nanocomplex in mice with Lewis lung carcinoma
Khranovska N.M., Skachkova O.V., Inomistova M.V. , Orel V.Е.
Summary. Antitumor, antimetastatic and immunomodulatory effects of combined therapy have been investigated, including the administration of dendritic cells (DCs) loaded with magnetic nanocomplex (MNC) and the effect of magnetic field in mice with Lewis lung carcinoma. It was found that intracutaneous administration of DCs loaded with MNC and the effect of magnetic field led to a significant reduction of the metastases number in the mice lungs compared to control and a decrease in their volume by 2 times, some decrease in the mass of the primary tumor due to a significant decrease in the number of S-phase cells. Combination therapy contributed to a decrease of TGF-β mRNA expression in the spleen and lymph nodes and a significant decrease in the expression of the FoxP3 mRNA transcription factor in spleen and inguinal lymph node cells. The obtained results testify to the prospect of the creation of new nanotechnologies with the use of antigen-presenting DCs and ferromagnets for cancer immunotherapy.
Leave a comment