Clinical and morphological characteristics in women with tumors of external genitals treated at National Cancer Institute

Summary. Маterials and methods. The article presents the results of a 3-year prospective study in women with tumors of external genitals, which were observated at National Cancer Institute between 2016–2018. Results. It was established progressive trend in the incidence of externalias tumors after 50 years (17.5%). The maximum incidence rate was established between 61–70 years (29.8%) and after 70 years (32.8%) (p<0.05). By T-criterion (TNM classification) the largest number were women with T2 clinical stage (53.4%), compared with T1 (27.6%) and T3 (10.6%) clinical stages (p<0.05). According to N-criterion women with N0 stage were majority — 70.2% vs N1 (20.6%) and N2 (4.6%) stages. According to M-criterion the majority of patients had M0 stage (90.1%) vs. 6.1% M1 and 3.8% Mx. By histopathological grading G1-differentiation (high) had 40.5% of patients, G2-differentiation (middle) — 38.9%, G3-differentiation (low) — 19.1%, and undifferentiated tumors (G4) were set in 1.5% women. According to FIGO-staging the majority of women had stage II (39.0%), with an equal distribution of patients I (20.6%) and ІІIA (18.3%) stages, the rarest stages were IVA (12.2%) and IVB (6.1%). Due to the primary localization, vulval tumors were diagnosed as the most often (64.9%); the tumors of vulvar lips accounted in 25.2% cases, tumors of Bartholin’s glands — 3.0%, clitoris — 4.6%. According to histological characteristics, most of the tumors were represented by squamous cell carcinoma (80.2%). Melanoma was revealed in 5.3% patients, carcinoma in 6.9%, sarcoma — in 6.1%; undifferentiated forms of cancer were set in 1.5% women. Conclusion. The concominant diseases in patients with external genital tumors were presented by urogenital inflammatory diseases (29.0%), in some patients — by ischemic heart disease (35.9%) and arterial hypertension (25.9%), rarely — by diabetes mellitus (13.7%), chronic bronchitis (10.7%) and stomach ulcer (13.7%).